Rajesh Gacche
Swami Ramanad Teerth Marathwada University, India
Title: Evaluation of curcumin capped copper nano-particles as possible inhibitors of human breast cancer cells and angiogenesis: A comparative study with native curcumin
Biography
Biography: Rajesh Gacche
Abstract
Synthesis of metal nanoparticles for improving therapeutic index and drug delivery is coming upas an attractive strategy in the mainstream of cancer therapeutic research. In the present study, curcumin capped copper nano-particles (CU-NPs) were evaluated as possible inhibitors of in vivo angiogenesis, pro-angiogenic cytokines involved in promoting tumor angiogenesis along with inhibition of cell proliferationand migration of breast cancer cell line MDA-MB-231. The anti-angiogenic potential was assessed using in vivo chorio-allantoic membrane (CAM) model. 3-(4, 5-Dimethylthiazol-2-yl)-2, 5-diphenyltetrazoliumbromide (MTT)-based cytotoxicity assay was used to assess the effect of CU-NPs against proliferation of breast cancer cell line. The wound healing migration assay was used to evaluate the effects of CU-NPs onthe migration ability of breast cancer cell line. Native curcumin (CU) was used as a reference compoundfor comparison purpose. The result of the present investigation indicates that CU-NPs could not demonstrate impressive anti-angiogenic or anticancer activities significantly as compared to native CU. Thepossible mechanisms of experimental outcomes will be discussed in the light of the methods of nano-particle synthesis in concert with the current state of the art literature.