Dagmara SÅ‚ota
Cracow University of Technology, Poland
Title: Physiochemical analysis and tribological properties of composite coatings for bone regeneration
Biography
Biography: Dagmara SÅ‚ota
Abstract
A key feature of medical devices, including implants, is their multifunctionality to ensure effective and long-lasting functionality. One solution that can ensure this is coating of implants, thus creating specific layers of biomaterial. Implant coating is one of the strategies used to increase biocompatibility as well as provide additional functions without changing the base material. In the case of materials developed for bone regeneration, hydroxyapatite (HA) coating can be used to add the desired osteointegration feature.
HA belongs to calcium phosphate ceramics, which are characterized by impressive biocompatibility and bioactivity. It also exhibits the ability to bond with natural tissue, which significantly eliminates the danger of implant loosening. Due to its structure, it can be modified with selected ions (e.g. Sr or Zn) to adduce additional antibacterial properties, or other active substances. Unfortunately, HA itself has low mechanical strength and high brittleness which limits its application. A solution to this problem may be to suspend HA in a polymer matrix to provide flexibility. The polymer phase is able to transfer stress while the resulting composite will not lose its bioactive properties given by the nature of HA.
In the present study, innovative ceramic-polymer composite coatings based on polyvinylpyrrolidone (PVP) and polyethylene glycol (PEG) containing glutathione and collagen for bone tissue regeneration were developed. The materials were subjected to tribological and physicochemical analysis, as well as incubation studies to determine their properties and potential for use as a carrier for the active substance. Moreover, the developed biomaterials have great potential due to the high biological value of the components used in their synthesis, which promote osteogenesis.